NON Mouse: Its Deteriorated Insulin Secretion
نویسندگان
چکیده
منابع مشابه
Early postprandial Insulin secretion: its relation to Insulin sensitivity
Background: Lack of first phase insulin secretion during oral glucose tolerance test [OGTT] in Type 2 Diabetes Mellitus (DM) is attributed to glucose toxicity. Alternatively, the role of insulin resistance in impaired insulin release secondary to lack of glucose entry into β cells may be responsible, but is not examined. Aim: The role of insulin sensitivity in 1 phase insulin secretion was asse...
متن کاملInsulin secretion in the conscious mouse is biphasic and pulsatile.
Islets in most species respond to increased glucose with biphasic insulin secretion, marked by a sharp first-phase peak and a slowly rising second phase. Mouse islets in vitro, however, lack a robust second phase. To date, this observation has not been extended in vivo. We thus compared insulin secretion from conscious mice with isolated mouse islets in vitro. The arterial plasma insulin respon...
متن کاملInsulin Secretion
Insulin is secreted from the -cells of the pancreatic islets by Ca 2 -dependent exocytosis of large dense core vesicles (LDCVs) (Ämmälä et al., 1993), a process that is triggered by glucose-induced electrical activity (Henquin and Meissner, 1984). In response to a step elevation of glucose, insulin secretion follows a characteristic biphasic time course (Curry et al., 1968): an initial transien...
متن کاملCLASSIC BlPHASlC INSULIN SECRETION: THE SLOW EMERGENCE OF ITS SIGNIFICANCE
Although initially described two decades ago, biphasic insulin secretion has gradually been understood to reflect p-cell rate sensitivity, be important in minimizing overinsulinization in normal individuals, be defective in non-insulin-dependent diabetes mellitus (NIDDM), and be useful as an early predictor in prediabetic individuals. Recently, a third phase of insulin secretion has been observ...
متن کاملInsulin secretion and its modulation by antiarrhythmic and sulfonylurea drugs.
Cardiovascular drugs such as antiarrhythmic agents with Vaughan Williams class Ia action have been found to induce a sporadic hypoglycemia. Recent investigation has revealed that these drugs induce insulin secretion from pancreatic beta-cells by inhibiting ATP-sensitive K+ (KATP) channels in a manner similar to sulfonylurea drugs. The mechanism underlying block of KATP channels by antiarrhythmi...
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ژورنال
عنوان ژورنال: Proceedings of The Japanese Association of Animal Models for Human Diseases
سال: 1989
ISSN: 0911-2057,1884-4189
DOI: 10.1538/expanim1985.5.24